Quantification of pathological microvessels in mice fed low- or high-cholesterol diets. The number of irregular and pathological microvessels was assessed in the hippocampus of C57BL/6J and LDLR-/- mice fed low- or high-cholesterol diets for 10 months (n = 5 per group). Microvessels were classified as normal, irregular, abnormally dilated, tortuous, or string-like. An average of 57 ± 4.6 microvessels were scored per animal. Abnormally dilated, tortuous and string vessels were summed as ''pathologic''. In panel (A), the average number of irregular, pathological or irregular + pathological microvessels per hippocampus is presented. In panel (B), the number of irregular + pathological vessels divided by the total number of vessels counted is presented. Comparisons were made between each experimental group and C57BL-LCD mice using unpaired t tests with the test of significance according to the Holm procedure. Asterisks indicate: * p = 0.01-0.05; ** p = 0.001-0.01; *** p < 0.001.