Quantification of microvascular parameters in mice fed low- or high-cholesterol diets. Vascular parameters were assessed stereologically in the hippocampus of C57BL/6J and LDLR-/- mice fed low- or high-cholesterol diets for 10 months. Quantitative analyses were performed on collagen IV immunoperoxidase-stained sections (n = 6 per group). Data are presented as total vascular density (A), total vessel length per hippocampus (B), and average microvessel diameter (C). Asterisks indicate values that are statistically different from C57BL-LCD (p < 0.05, Tukey HSD).