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Figure 2 | Molecular Neurodegeneration

Figure 2

From: Neuroprotective effects of blockers for T-type calcium channels

Figure 2

Neuronal protection by trimethadione. (A) E18 hippocampal neurons cultured in neurobasal medium with 2% FBS for 7-8 days. Medium was replenished at the 8th day of culture and neurons treated with either 0 mM, 0.3 mM, 0.6 mM, or 0.9 mM (control, n = 16; treatment groups, n = 8 each). Cell death was performed with LDH assay 10 DIV (24 h later); mean LDH value expressed as % of control. *p ≤ 0.05 and **p ≤ 0.01 compared with the control condition. Raw data was used for one-way ANOVA. (B) E18 cortical neurons cultured in neurobasal medium with 2% FBS for 7-8 days. Medium was replenished on the 8th day and neurons treated with either 0 mM, 0.3 mM, 0.6 mM, or 0.9 mM (n = 12 each). Cell viability was performed with LDH assay on 10 DIV. Mean LDH value expressed as % of control. *p ≤ 0.05 compared with the control using student's t test. Raw data was used for one-way ANOVA.

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