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Table 3 Expression of SORL1 isoforms relative to Braak stage.

From: Expression of SORL1 and a novel SORL1 splice variant in normal and Alzheimers disease brain

SORL1 ISOFORM

Braak

N

Mean ± SE

P Value*

Total SORL1

0-II

20

2.167 ± 0.150

0.009

 

III-V

8

1.507 ± 0.228

0.031*

 

VI

29

1.537 ± 0.140

0.004*

FL-SORL1

0-II

20

2.121 ± 0.150

0.008

 

III-V

8

1.470 ± 0.222

0.031*

 

VI

29

1.493 ± 0.138

0.003*

Delta-2-SORL1

0-II

20

0.046 ± 0.003

0.339

 

III-V

8

0.037 ± 0.006

 
 

VI

29

0.044 ± 0.003

 

Delta-2-SORL1 (%)

0-II

20

2.26 ± 0.16

0.002

 

III-V

8

2.48 ± 0.15

0.454*

 

VI

29

3.02 ± 0.14

0.001*

  1. For each isoform, the initial p value is the overall ANOVA p value, while the p values marked with asterisks refer to LSD post-hoc comparisons with the Braak 0-II group.
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Molecular Neurodegeneration

ISSN: 1750-1326