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Table 5 Expression of SORL1 isoforms in human brain as a function of rs661057 genotype.

From: Expression of SORL1 and a novel SORL1 splice variant in normal and Alzheimers disease brain

SORL1 ISOFORM

Rs661057

N

Mean ± SE

P Value*

Total SORL1

T/T

18

2.249 ± 0.196

<0.001

 

T/C

30

1.383 ± 0.086

<0.001*

 

C/C

8

2.081 ± 0.295

0.552*

FL-SORL1

T/T

18

2.199 ± 0.195

<0.001

 

T/C

30

1.344 ± 0.084

<0.001*

 

C/C

8

2.033 ± 0.292

0.553*

Delta-2-SORL1

T/T

18

0.050 ± 0.003

0.017

 

T/C

30

0.039 ± 0.002

0.007*

 

C/C

8

0.048 ± 0.007

0.706*

Delta-2-SORL1 (%)

T/T

18

2.36 ± 0.20

0.072

 

T/C

30

2.88 ± 0.14

 
 

C/C

8

2.46 ± 0.28

 
  1. For each isoform, the initial p value is the overall ANOVA p value, while the p values marked with asterisks refer to LSD post-hoc comparisons with the rs661057 T/T group.