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Table 1 Selected genes up-regulated in severe AD

From: Independent component analysis of Alzheimer's DNA microarray gene expression data

Gene name Description Chromosomal location
Immunity-related protein
AMIGO2 adhesion molecule with Ig-like domain 2 chr12q13.11
BTG1 B-cell translocation gene 1, anti-proliferative chr12q22
CD24 CD24 molecule chr6q21
CD44 CD44 molecule (Indian blood group) chr11p13
CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4 chr17q24-q25
IFITM1 interferon-induced transmembrane protein 1 (9–27) chr11p15.5
IFITM2 interferon-induced transmembrane protein 2 (1–8D) chr11p15.5
IRF7 interferon regulatory factor 7 chr11p15.5
IFI44L interferon-induced protein 44-like chr1p31.1
IL4R interleukin 4 receptor chr16p12.1-p11.2
IRAK1 interleukin-1 receptor-associated kinase 1 chrXq28
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha chr14q13
Metal-related protein
CAMK2B calcium/calmodulin-dependent protein kinase (CaM kinase) II beta chr22q12|7p14.3-p14.1
CALM1 calmodulin 1 (phosphorylase kinase, delta) chr14q24-q31
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 chr7q31.2-q31.3
CHGB chromogranin B (secretogranin 1) chr20pter-p12
LOC728320/LTF lactotransferrin/similar to lactotransferrin chr3q21-q23
MPPE1 metallophosphoesterase 1 chr18p11.21
MT1F metallothionein 1F chr16q13
MT1M metallothionein 1M chr16q13
MBP myelin basic protein chr18q23
SCGN secretagogin, EF-hand calcium binding protein chr6p22.3-p22.1
SLC24A3 solute carrier family 24(sodium/potassium/calcium exchanger), member 3 chr20p13
SLC7A11 solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 chr4q28-q32
ZIC1 zinc family member 1 (odd-paired homolog, Drosophila) chr3q24
ZBTB20 zinc finger and BTB domain containing 20 chr3q13.2
ZNF500 zinc finger protein 500 chr16p13.3
ZNF580 zinc finger protein 580 chr19q13.42
ZNF652 zinc finger protein 652 chr17q21.32
ZNF710 zinc finger protein 710 chr15q26.1
Neuropeptide
NMB neuromedin B chr15q22-qter
Ribosomal Protein
LOC644166/LO C644191/LOC728937/RPS26 ribosomal protein S26/similar to 40S ribosomal protein S26 chr12q13/chr17q21.31/chr2q31.1/chr4q26
SORBS3 sorbin and SH3 domain containing 3 chr8p21.3
Cytoskeleton Protein
COL21A1 collagen, type XXI, alpha 1 chr6p12.3-p11.2|6p12.3-p11.2
CTBP1 C-terminal binding protein 1 chr4p16
CAPZA2 capping protein (actin filament) muscle Z-line, alpha 2 chr7q31.2-q31.3
FLNA filamin A, alpha (actin binding protein 280) chrXq28
Cholesterol metabolism
APOC2/APOC4 apolipoprotein C-II/apolipoprotein C-IV chr19q13.2
APOE apolipoprotein E chr19q13.2
ABCA1 ATP-binding cassette, sub-family A (ABC1), member 1 chr9q31.1
Lipoprotein
GAD2 glutamate decarboxylase 2 (pancreatic islets and brain, 65 kDa) chr10p11.23
LDLRAP1 low density lipoprotein receptor adaptor protein 1 chr1p36-p35
Binding protein
AEBP1 AE binding protein 1 chr7p13
TAP1 transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) chr6p21.3
UBAP2L ubiquitin associated protein 2-like chr1q21.3
Membrane Protein
HLA-DRB4 major histocompatibility complex, class II, DR beta 4 chr6p21.3
TRHDE thyrotropin-releasing hormone degrading enzyme chr12q15-q21
TMEM92 Transmembrane protein 92 chr17q21.33
SERPINA3 serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 chr14q32.1
Others
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) chr11p15.5
GSTM5 glutathione S-transferase M5 chr1p13.3
SPARC secreted protein, acidic, cysteine-rich (osteonectin) chr5q31.3-q32