Table 1 Selected genes up-regulated in severe AD
From: Independent component analysis of Alzheimer's DNA microarray gene expression data
Gene name | Description | Chromosomal location |
|---|---|---|
Immunity-related protein | ||
AMIGO2 | adhesion molecule with Ig-like domain 2 | chr12q13.11 |
BTG1 | B-cell translocation gene 1, anti-proliferative | chr12q22 |
CD24 | CD24 molecule | chr6q21 |
CD44 | CD44 molecule (Indian blood group) | chr11p13 |
CDC42EP4 | CDC42 effector protein (Rho GTPase binding) 4 | chr17q24-q25 |
IFITM1 | interferon-induced transmembrane protein 1 (9–27) | chr11p15.5 |
IFITM2 | interferon-induced transmembrane protein 2 (1–8D) | chr11p15.5 |
IRF7 | interferon regulatory factor 7 | chr11p15.5 |
IFI44L | interferon-induced protein 44-like | chr1p31.1 |
IL4R | interleukin 4 receptor | chr16p12.1-p11.2 |
IRAK1 | interleukin-1 receptor-associated kinase 1 | chrXq28 |
NFKBIA | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | chr14q13 |
Metal-related protein | ||
CAMK2B | calcium/calmodulin-dependent protein kinase (CaM kinase) II beta | chr22q12|7p14.3-p14.1 |
CALM1 | calmodulin 1 (phosphorylase kinase, delta) | chr14q24-q31 |
CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | chr7q31.2-q31.3 |
CHGB | chromogranin B (secretogranin 1) | chr20pter-p12 |
LOC728320/LTF | lactotransferrin/similar to lactotransferrin | chr3q21-q23 |
MPPE1 | metallophosphoesterase 1 | chr18p11.21 |
MT1F | metallothionein 1F | chr16q13 |
MT1M | metallothionein 1M | chr16q13 |
MBP | myelin basic protein | chr18q23 |
SCGN | secretagogin, EF-hand calcium binding protein | chr6p22.3-p22.1 |
SLC24A3 | solute carrier family 24(sodium/potassium/calcium exchanger), member 3 | chr20p13 |
SLC7A11 | solute carrier family 7, (cationic amino acid transporter, y+ system) member 11 | chr4q28-q32 |
ZIC1 | zinc family member 1 (odd-paired homolog, Drosophila) | chr3q24 |
ZBTB20 | zinc finger and BTB domain containing 20 | chr3q13.2 |
ZNF500 | zinc finger protein 500 | chr16p13.3 |
ZNF580 | zinc finger protein 580 | chr19q13.42 |
ZNF652 | zinc finger protein 652 | chr17q21.32 |
ZNF710 | zinc finger protein 710 | chr15q26.1 |
Neuropeptide | ||
NMB | neuromedin B | chr15q22-qter |
Ribosomal Protein | ||
LOC644166/LO C644191/LOC728937/RPS26 | ribosomal protein S26/similar to 40S ribosomal protein S26 | chr12q13/chr17q21.31/chr2q31.1/chr4q26 |
SORBS3 | sorbin and SH3 domain containing 3 | chr8p21.3 |
Cytoskeleton Protein | ||
COL21A1 | collagen, type XXI, alpha 1 | chr6p12.3-p11.2|6p12.3-p11.2 |
CTBP1 | C-terminal binding protein 1 | chr4p16 |
CAPZA2 | capping protein (actin filament) muscle Z-line, alpha 2 | chr7q31.2-q31.3 |
FLNA | filamin A, alpha (actin binding protein 280) | chrXq28 |
Cholesterol metabolism | ||
APOC2/APOC4 | apolipoprotein C-II/apolipoprotein C-IV | chr19q13.2 |
APOE | apolipoprotein E | chr19q13.2 |
ABCA1 | ATP-binding cassette, sub-family A (ABC1), member 1 | chr9q31.1 |
Lipoprotein | ||
GAD2 | glutamate decarboxylase 2 (pancreatic islets and brain, 65 kDa) | chr10p11.23 |
LDLRAP1 | low density lipoprotein receptor adaptor protein 1 | chr1p36-p35 |
Binding protein | ||
AEBP1 | AE binding protein 1 | chr7p13 |
TAP1 | transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) | chr6p21.3 |
UBAP2L | ubiquitin associated protein 2-like | chr1q21.3 |
Membrane Protein | ||
HLA-DRB4 | major histocompatibility complex, class II, DR beta 4 | chr6p21.3 |
TRHDE | thyrotropin-releasing hormone degrading enzyme | chr12q15-q21 |
TMEM92 | Transmembrane protein 92 | chr17q21.33 |
SERPINA3 | serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3 | chr14q32.1 |
Others | ||
CDKN1C | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | chr11p15.5 |
GSTM5 | glutathione S-transferase M5 | chr1p13.3 |
SPARC | secreted protein, acidic, cysteine-rich (osteonectin) | chr5q31.3-q32 |