Table 2 Selected genes down-regulated in severe AD
From: Independent component analysis of Alzheimer's DNA microarray gene expression data
Gene name | Description | Chromosomal location |
|---|---|---|
Immunity | ||
CD22/MAG | CD22 molecule/myelin associated glycoprotein | chr19q13.1 |
Metal-related protein | ||
CABP1 | calcium-binding protein 1 | chr12q24.31 |
CACNG3 | calcium channel, voltage-dependent, gamma subunit 3 | chr16p12-p13.1 |
CAMK2B | calcium/calmodulin-dependent protein kinase (CaM kinase) II beta | chr22q12|7p14.3-p14.1 |
CAMK1G | calcium/calmodulin-dependent protein kinase IG | chr1q32-q41 |
CAPZB | capping protein (actin filament) muscle Z-line, beta | chr1p36.1 |
MET | met proto-oncogene (hepatocyte growth factor receptor) | chr7q31 |
ZNF365 | zinc finger protein 365 | chr10q21.2 |
TFRC | transferrin receptor (p90, CD71) | chr3q29 |
Neuropeptide | ||
APLP2 | amyloid beta (A4) precursor-like protein 2 | chr11q23-q25|11 q24 |
CYP26B1 | cytochrome P450, family 26, subfamily B, polypeptide 1 | chr2p13.3 |
NEFH | neurofilament, heavy polypeptide 200 kDa | chr22q12.2 |
NEFL | neurofilament, light polypeptide 68 kDa | chr8p21 |
NPY | neuropeptide Y | chr7p15.1 |
NTRK2 | neurotrophic tyrosine kinase, receptor, type 2 | chr9q22.1 |
SERPINI1 | serpin peptidase inhibitor, clade I (neuroserpin), member 1 | chr3q26.1 |
OLIG2 | oligodendrocyte lineage transcription factor 2 | chr21q22.11 |
NRSN2 | neurensin 2 | chr20p13 |
Ribosomal Protein | ||
CSPG5 | chondroitin sulfate proteoglycan 5 (neuroglycan C) | chr3p21.3 |
C1orf115 | chromosome 1 open reading frame 115 | chr1q41 |
C20orf149 | chromosome 20 open reading frame 149 | chr20q13.33 |
C9orf16 | chromosome 9 open reading frame 16 | chr9q34.1 |
HNRPA3/HNRPA3P1 | heterogeneous nuclear ribonucleoprotein A3 pseudogene 1/heterogeneous nuclear ribonucleoprotein A3 | chr10q11.21/chr2q31.2 |
Cytoskeleton Protein | ||
ACTB | actin, beta | chr7p15-p12 |
SMARCA4 | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 | chr19p13.2 |
Oncogene | ||
ABCA2 | ATP-binding cassette, sub-family A (ABC1), member 2 | chr9q34 |
ATP6V0C | ATPase, H+ transporting, lysosomal 16 kDa, V0 subunit c | chr16p13.3 |
ATP13A2 | ATPase type 13A2 | chr1p36 |
BCAS1 | breast carcinoma amplified sequence 1 | chr20q13.2-q13. 3 |
Binding Protein | ||
CABP1 | calcium-binding protein 1 | chr12q24.31 |
Membrane Protein | ||
RIMS3 | regulating synaptic membrane exocytosis 3 | chr1pter-p22.2 |
PCSK1 | proprotein convertase subtilisin/kexin type 1 | chr5q15-q21 |
RIMS2 | regulating synaptic membrane exocytosis 2 | chr8q22.3 |
Lipoprotein | ||
GRIN1 | glutamate receptor, ionotropic, N-methyl D-aspartate 1 | chr9q34.3 |
MBP | myelin basic protein | chr18q23 |
MOBP | myelin-associated oligodendrocyte basic protein | chr3p22.1 |
Phosphorylation-related Protein | ||
PIP3-E | phosphoinositide-binding protein PIP3-E | chr6q25.2 |
PLD3 | phospholipase D family, member 3 | chr19q13.2 |
PTPRT | protein tyrosine phosphatase, receptor type, T | chr20q12-q13 |
Others | ||
EIF5A | eukaryotic translation initiation factor 5A | chr17p13-p12 |
ISG15 | ISG15 ubiquitin-like modifier | chr1p36.33 |
RCAN2 | regulator of calcineurin 2 | chr6p12.3 |
RGS4 | regulator of G-protein signaling 4 | chr1q23.3 |
SRD5A1 | steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) | chr5p15 |