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Table 2 Selected genes down-regulated in severe AD

From: Independent component analysis of Alzheimer's DNA microarray gene expression data

Gene name Description Chromosomal location
Immunity
CD22/MAG CD22 molecule/myelin associated glycoprotein chr19q13.1
Metal-related protein
CABP1 calcium-binding protein 1 chr12q24.31
CACNG3 calcium channel, voltage-dependent, gamma subunit 3 chr16p12-p13.1
CAMK2B calcium/calmodulin-dependent protein kinase (CaM kinase) II beta chr22q12|7p14.3-p14.1
CAMK1G calcium/calmodulin-dependent protein kinase IG chr1q32-q41
CAPZB capping protein (actin filament) muscle Z-line, beta chr1p36.1
MET met proto-oncogene (hepatocyte growth factor receptor) chr7q31
ZNF365 zinc finger protein 365 chr10q21.2
TFRC transferrin receptor (p90, CD71) chr3q29
Neuropeptide
APLP2 amyloid beta (A4) precursor-like protein 2 chr11q23-q25|11 q24
CYP26B1 cytochrome P450, family 26, subfamily B, polypeptide 1 chr2p13.3
NEFH neurofilament, heavy polypeptide 200 kDa chr22q12.2
NEFL neurofilament, light polypeptide 68 kDa chr8p21
NPY neuropeptide Y chr7p15.1
NTRK2 neurotrophic tyrosine kinase, receptor, type 2 chr9q22.1
SERPINI1 serpin peptidase inhibitor, clade I (neuroserpin), member 1 chr3q26.1
OLIG2 oligodendrocyte lineage transcription factor 2 chr21q22.11
NRSN2 neurensin 2 chr20p13
Ribosomal Protein
CSPG5 chondroitin sulfate proteoglycan 5 (neuroglycan C) chr3p21.3
C1orf115 chromosome 1 open reading frame 115 chr1q41
C20orf149 chromosome 20 open reading frame 149 chr20q13.33
C9orf16 chromosome 9 open reading frame 16 chr9q34.1
HNRPA3/HNRPA3P1 heterogeneous nuclear ribonucleoprotein A3 pseudogene 1/heterogeneous nuclear ribonucleoprotein A3 chr10q11.21/chr2q31.2
Cytoskeleton Protein
ACTB actin, beta chr7p15-p12
SMARCA4 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 chr19p13.2
Oncogene
ABCA2 ATP-binding cassette, sub-family A (ABC1), member 2 chr9q34
ATP6V0C ATPase, H+ transporting, lysosomal 16 kDa, V0 subunit c chr16p13.3
ATP13A2 ATPase type 13A2 chr1p36
BCAS1 breast carcinoma amplified sequence 1 chr20q13.2-q13. 3
Binding Protein
CABP1 calcium-binding protein 1 chr12q24.31
Membrane Protein
RIMS3 regulating synaptic membrane exocytosis 3 chr1pter-p22.2
PCSK1 proprotein convertase subtilisin/kexin type 1 chr5q15-q21
RIMS2 regulating synaptic membrane exocytosis 2 chr8q22.3
Lipoprotein
GRIN1 glutamate receptor, ionotropic, N-methyl D-aspartate 1 chr9q34.3
MBP myelin basic protein chr18q23
MOBP myelin-associated oligodendrocyte basic protein chr3p22.1
Phosphorylation-related Protein
PIP3-E phosphoinositide-binding protein PIP3-E chr6q25.2
PLD3 phospholipase D family, member 3 chr19q13.2
PTPRT protein tyrosine phosphatase, receptor type, T chr20q12-q13
Others
EIF5A eukaryotic translation initiation factor 5A chr17p13-p12
ISG15 ISG15 ubiquitin-like modifier chr1p36.33
RCAN2 regulator of calcineurin 2 chr6p12.3
RGS4 regulator of G-protein signaling 4 chr1q23.3
SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1) chr5p15