Acute administration of latrepirdine increases ISF Aβ
levels 9-10 hours following treatment. A single i.p. treatment of latrepirdine (SD = 30.94, t(4) = 2.997, p = 0.04), but not vehicle (SD = 5.68, t(4) = 0.775, p = 0.48), produces an increase in ISF Aβx-40 levels from baseline at 9-10 hours post-treatment (a). This increase in ISF Aβx-40 level was also determined to be significantly higher than ISF Aβx-40 levels observed in vehicle treated animals at 9-10 hours post-treatment (SD = 30.94, t(5) = 3.31, p = 0.01; b). Data are represented as mean percent of baseline +/- S.E.M. *Value represents a significant difference as determined by paired samples t-test (a) or independent samples t-test (b), two-tailed α = 0.05, *p < 0.05.