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Table 1 Demographic, clinical and genetic characteristics of patients with AD and controls

From: Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y polymorphism in Alzheimer's disease

Characteristic AD patients (n = 452) Controls (n = 234) P-value
Sex, f/m (%) 299/153 (66.2/33.8) 127/89 (58.8/41.2) 0.071*
  n = 452 n = 216  
Age, years, 76.2 ± 6.4 (60-102) 75.9 ± 7.1 (65-94) 0.215
Mean ± SD (range) n = 341 n = 216  
MMSE score, Median (25th -- 75th percentiles) 22 (19-25) n = 367 29 (29-30) n = 113 <0.001
T-tau (pg/ml), Mean ± SD 621 ± 319 n = 260 376 ± 162 n = 117 <0.001
P-tau181 (pg/ml), Mean ± SD 76.9 ± 31.2 n = 260 63.3 ± 19.9 n = 91 <0.001
1-42 (pg/ml), Mean ± SD 409 ± 100 n = 260 720 ± 200 n = 117 <0.001
SPs and NFTs score, Median (25th -- 75thpercentiles) 7 (6-8.5) n = 65 1 (0-3) n = 80 <0.001
APOE ε4 allele-carriers n (%)
number of ε4 alleles:
   
   0 128 (28.3) 156 (72.2) <0.001*
   1 238 (52.7) 55 (25.5) <0.001*
   2 86 (19.0) 5 (2.3) <0.001*
  n = 452 n = 216  
  1. *Fisher's Exact Test, Mann-Whitney U-test. AD = Alzheimer's disease, SD = Standard Deviation, MMSE = Mini Mental State Examination, Aβ = β-amyloid, SPs = senile plaques, NFTs = neurofibrillary tangles