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Table 1 Demographic, clinical and genetic characteristics of patients with AD and controls

From: Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y polymorphism in Alzheimer's disease

Characteristic

AD patients (n = 452)

Controls (n = 234)

P-value

Sex, f/m (%)

299/153 (66.2/33.8)

127/89 (58.8/41.2)

0.071*

 

n = 452

n = 216

 

Age, years,

76.2 ± 6.4 (60-102)

75.9 ± 7.1 (65-94)

0.215

Mean ± SD (range)

n = 341

n = 216

 

MMSE score, Median (25th -- 75th percentiles)

22 (19-25) n = 367

29 (29-30) n = 113

<0.001

T-tau (pg/ml), Mean ± SD

621 ± 319 n = 260

376 ± 162 n = 117

<0.001

P-tau181 (pg/ml), Mean ± SD

76.9 ± 31.2 n = 260

63.3 ± 19.9 n = 91

<0.001

1-42 (pg/ml), Mean ± SD

409 ± 100 n = 260

720 ± 200 n = 117

<0.001

SPs and NFTs score, Median (25th -- 75thpercentiles)

7 (6-8.5) n = 65

1 (0-3) n = 80

<0.001

APOE ε4 allele-carriers n (%)

number of ε4 alleles:

   

   0

128 (28.3)

156 (72.2)

<0.001*

   1

238 (52.7)

55 (25.5)

<0.001*

   2

86 (19.0)

5 (2.3)

<0.001*

 

n = 452

n = 216

 
  1. *Fisher's Exact Test, Mann-Whitney U-test. AD = Alzheimer's disease, SD = Standard Deviation, MMSE = Mini Mental State Examination, Aβ = β-amyloid, SPs = senile plaques, NFTs = neurofibrillary tangles