Skip to main content

Table 4 CSF biomarkers and neuropathological score in relation to UCHL1 allele A-carrier status in AD patients and control subjects

From: Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y polymorphism in Alzheimer's disease

  UCHL1allele A-carrier status  
CSF Biomarker positive negative P-value*
T-tau (pg/ml), Mean ± SD    
   AD patients 640 ± 368 613 ± 297 0.790
   Controls 367 ± 175 381 ± 156 0.528
P-tau181 (pg/ml), Mean ± SD    
   AD patients 80.6 ± 35.1 75.3 ± 29.4 0.434
   Controls 58.8 ± 16.7 65.7 ± 21.1 0.159
1-42 (pg/ml), Mean ± SD    
   AD patients 406 ± 91.5 410 ± 104 0.996
   Controls 749 ± 195 703 ± 202 0.246
SPs and NFTs score    
Median (25th -- 75th percentiles)    
   AD patients 7 (5-8) 7 (6-9) 0.495
   Controls 2 (0-3.5) 0 (0-2) 0.122
  1. CSF = cerebrospinal fluid, AD = Alzheimer's disease, SPs = senile plaques, NFTs = neurofibrillary tangles, Aβ = β-amyloid, *Mann-Whitney U-test