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Table 4 CSF biomarkers and neuropathological score in relation to UCHL1 allele A-carrier status in AD patients and control subjects

From: Ubiquitin carboxy-terminal hydrolase L1 (UCHL1) S18Y polymorphism in Alzheimer's disease

 

UCHL1allele A-carrier status

 

CSF Biomarker

positive

negative

P-value*

T-tau (pg/ml), Mean ± SD

   

   AD patients

640 ± 368

613 ± 297

0.790

   Controls

367 ± 175

381 ± 156

0.528

P-tau181 (pg/ml), Mean ± SD

   

   AD patients

80.6 ± 35.1

75.3 ± 29.4

0.434

   Controls

58.8 ± 16.7

65.7 ± 21.1

0.159

Aβ1-42 (pg/ml), Mean ± SD

   

   AD patients

406 ± 91.5

410 ± 104

0.996

   Controls

749 ± 195

703 ± 202

0.246

SPs and NFTs score

   

Median (25th -- 75th percentiles)

   

   AD patients

7 (5-8)

7 (6-9)

0.495

   Controls

2 (0-3.5)

0 (0-2)

0.122

  1. CSF = cerebrospinal fluid, AD = Alzheimer's disease, SPs = senile plaques, NFTs = neurofibrillary tangles, Aβ = β-amyloid, *Mann-Whitney U-test
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Molecular Neurodegeneration

ISSN: 1750-1326