Figure 3
From: Phospholipase A2inhibitors protect against prion and Aβ mediated synapse degeneration
PLA 2 inhibitors protected against Aβ 1-42 induced synapse degeneration. (A) The synaptophysin content of cortical neurones pre-treated with a vehicle control (■), 1 μM AACOCF3 (○) or 1 μM MAFP (●) and incubated with varying concentrations of Aβ1-42 for 24 hours. Values shown are the mean average amount of synaptophysin ± SD, n = 12. (B) The synaptophysin content of hippocampal neurones pre-treated with a vehicle control (■) or 1 μM AACOCF3 (○) and incubated with varying concentrations of Aβ1-42 for 24 hours. Values shown are the mean average amount of synaptophysin ± SD, n = 6.