Figure 4
From: Phospholipase A2inhibitors protect against prion and Aβ mediated synapse degeneration
PLA 2 inhibitors protected against 7PA2-CM induced synapse degeneration. (A) The synaptophysin content of cortical neurones incubated for 24 hours with 7PA2-CM (□) or CHO-CM (■). Values shown are the mean average amount of synaptophysin ± SD, n = 12. (B) The synaptophysin content of cortical neurones incubated for pre-treated with a vehicle control (□), 1 μM AACOCF3 (■) or 1 μM MAFP (striped bars) and incubated with doubling dilutions of 7PA2-CM for 24 hours. Values shown are the mean average amount of synaptophysin ± SD, n = 12.