Skip to main content

Table 2 PAF receptor antagonists reduced synapse degeneration induced by Aβ1-42or PLAP.

From: Phospholipase A2inhibitors protect against prion and Aβ mediated synapse degeneration

  Synaptophysin (units/106cells)
Treatment Vehicle Hexa-PAF Ginkgolide B CV6209
Vehicle 100 ± 6 98 ± 7 102 ± 5 96 ± 8
100 nM Aβ 1-42 32 ± 6 94 ± 6 98 ± 9 89 ± 8
1 μM PLAP 27 ± 7 95 ± 8 94 ± 8 82 ± 7
  1. Primary cortical neurones were pre-treated with a vehicle control, or with PAF receptor antagonists (2 μM Hexa-PAF, 1 μM ginkgolide or 2 μM CV6209) for 1 hour prior to incubation with Aβ1-42 or PLAP as shown for 24 hours. Values shown are the mean average amount of synaptophysin (units/106 cells) ± SD, n = 12.