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Table 2 PAF receptor antagonists reduced synapse degeneration induced by Aβ1-42or PLAP.

From: Phospholipase A2inhibitors protect against prion and Aβ mediated synapse degeneration

 

Synaptophysin (units/106cells)

Treatment

Vehicle

Hexa-PAF

Ginkgolide B

CV6209

Vehicle

100 ± 6

98 ± 7

102 ± 5

96 ± 8

100 nM Aβ 1-42

32 ± 6

94 ± 6

98 ± 9

89 ± 8

1 μM PLAP

27 ± 7

95 ± 8

94 ± 8

82 ± 7

  1. Primary cortical neurones were pre-treated with a vehicle control, or with PAF receptor antagonists (2 μM Hexa-PAF, 1 μM ginkgolide or 2 μM CV6209) for 1 hour prior to incubation with Aβ1-42 or PLAP as shown for 24 hours. Values shown are the mean average amount of synaptophysin (units/106 cells) ± SD, n = 12.