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Table 3 A prostanoid E receptor antagonist protected against synapse degeneration

From: Phospholipase A2inhibitors protect against prion and Aβ mediated synapse degeneration

 

Synaptophysin (units)

Treatment

Vehicle control

Prostanoid E receptor antagonist AH13205

Prostanoid D receptor antagonist BWA868C

Vehicle control

100 ± 6

99 ± 7

99 ± 3

200 nM PrP82-146

22 ± 5

87 ± 8

30 ± 7

100 nM Aβ 1-42

32 ± 6

93 ± 5

34 ± 6

1 μM PLAP

27 ± 7

91 ± 7

38 ± 6

10 nM PAF

31 ± 4

85 ± 9

32 ± 5

10 nM Prostaglandin E 2

30 ± 5

97 ± 3

33 ± 6

  1. Primary cortical neurones were pre-treated with a vehicle control, a prostanoid E receptor antagonist (100 nM AH13205) or a prostanoid D receptor antagonist (100 nM BWA868C) for 1 hour prior to incubation with PrP82-146, Aβ1-42, PLAP, PAF or prostaglandin E2 as shown for 24 hours. Values shown are the mean average amount of synaptophysin ± SD, n = 9.