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Table 3 A prostanoid E receptor antagonist protected against synapse degeneration

From: Phospholipase A2inhibitors protect against prion and Aβ mediated synapse degeneration

  Synaptophysin (units)
Treatment Vehicle control Prostanoid E receptor antagonist AH13205 Prostanoid D receptor antagonist BWA868C
Vehicle control 100 ± 6 99 ± 7 99 ± 3
200 nM PrP82-146 22 ± 5 87 ± 8 30 ± 7
100 nM Aβ 1-42 32 ± 6 93 ± 5 34 ± 6
1 μM PLAP 27 ± 7 91 ± 7 38 ± 6
10 nM PAF 31 ± 4 85 ± 9 32 ± 5
10 nM Prostaglandin E 2 30 ± 5 97 ± 3 33 ± 6
  1. Primary cortical neurones were pre-treated with a vehicle control, a prostanoid E receptor antagonist (100 nM AH13205) or a prostanoid D receptor antagonist (100 nM BWA868C) for 1 hour prior to incubation with PrP82-146, Aβ1-42, PLAP, PAF or prostaglandin E2 as shown for 24 hours. Values shown are the mean average amount of synaptophysin ± SD, n = 9.