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Figure 4 | Molecular Neurodegeneration

Figure 4

From: Soluble amyloid-β, effect on cerebral arteriolar regulation and vascular cells

Figure 4

Scavenging of oxygen radical production in rat cerebral microvascular endothelial and smooth muscle cells. ROS production was measured in rat cerebral microvascular endothelial and smooth muscle cells using the ROS sensitive dye MitoTracker Red CM-H2XRos (5 μmol/L). MnTBAP (100 μmol/L) inhibits the increase in (A) Aβ1-40- and (B) Aβ1-42-induced oxygen radical production both in cultured rat cerebral microvascular endothelial cells and in smooth muscle cells (C and D). † denotes p > 0.05 from Control; * denotes p > 0.05 MnTBAP versus respective Control (ANOVA). N > three replicates with three cultures per replicate (n ≥ 9).

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