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Figure 5 | Molecular Neurodegeneration

Figure 5

From: Tetrabenazine is neuroprotective in Huntington's disease mice

Figure 5

Neuropathological analysis of WT and YAC128 mice. A, Average brain weight of 13-month-old WT and YAC128 (YAC) mice. The brain weight of control YAC128 is significantly reduced compared with control WT group (p < 0.05). The brain weight of YAC128 mice fed with TBZ is significantly increased compared with brain weight of control (Ctrl) YAC128 mice (*** p < 0.05). B, Representative NeuN staining of striatal sections from 13-month-old WT and YAC128 mice. C, Average striatal neuronal counts of 13-month-old WT and YAC128 mice. Control YAC128 mice showed significant striatal neuronal loss (p < 0.05) compared with control WT mice. YAC128 mice fed with TBZ display significantly increased striatal neuronal counts compared with control YAC128 mice (*** p < 0.05) but significantly reduced neuronal counts compared with WT mice (*** p < 0.05). A, C, For each group of mice, the results are shown as mean ± SEM. Ctrl, Control.

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