Skip to main content
Figure 6 | Molecular Neurodegeneration

Figure 6

From: Distinct cerebrospinal fluid amyloid β peptide signatures in sporadic and PSEN1A431E-associated familial Alzheimer's disease

Figure 6

Aβ1-16 does not inhibit hippocampal long-term potentiation (LTP). (A) Control LTP elicited by three trains (20 impulses, 50 Hz) separated by 5 seconds. Data points are normalized field EPSP initial slope measurements ± standard errors of the mean. Average (n = 20) field EPSPs before and 60 minutes after the induction of LTP are shown on top. (B) LTP elicited in the presence of oligomerized Aβ1-42 (positive control). (C) LTP elicited in the presence of Aβ1-16. Scale bars represent 5 ms and 0.1 mV. (D) Comparison between LTP 60 minutes after the induction in control, in Aβ1-16 and in Aβ1-42.

Back to article page

Molecular Neurodegeneration

ISSN: 1750-1326