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Table 1 The kinetic analysis of α-Syn variants in this study.

From: The inhibitory effect of pyrroloquinoline quinone on the amyloid formation and cytotoxicity of truncated alpha-synuclein

Lag-time (h)

Full-length α-Syn

α-Syn110

α-Syn119

α-Syn133

α-Syn (70 μM)

21.4

4.8

14.3

36.1

Truncated α-Syn (35 μM) +

Full-length α-Syn (35 μM)

-

5.0

8.8

31.4

α-Syn (70 μM) +

PQQ (280 μM)

30.5

8.6

23.5

47.7

  1. The lag time analysis of fibril formation was calculated from fitting-curve of TfT fluorescence was provided by PRISM (GraphPad Software)