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Table 1 The kinetic analysis of α-Syn variants in this study.

From: The inhibitory effect of pyrroloquinoline quinone on the amyloid formation and cytotoxicity of truncated alpha-synuclein

Lag-time (h) Full-length α-Syn α-Syn110 α-Syn119 α-Syn133
α-Syn (70 μM) 21.4 4.8 14.3 36.1
Truncated α-Syn (35 μM) +
Full-length α-Syn (35 μM)
- 5.0 8.8 31.4
α-Syn (70 μM) +
PQQ (280 μM)
30.5 8.6 23.5 47.7
  1. The lag time analysis of fibril formation was calculated from fitting-curve of TfT fluorescence was provided by PRISM (GraphPad Software)