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Table 2 Association between health behaviors and cognitive function as a function of APOE ε4 status adjusted for socioeconomic variables.

From: Effect of Apolipoprotein E ε4 on the association between health behaviors and cognitive function in late midlife

  Memory Reasoning Phonemic fluency Semantic fluency pfor interaction
Health behaviors Difference(95% CI) Difference(95% CI) Difference(95% CI) Difference(95% CI)  
Current smoking §      
APOE ε4 non-carriers -2.49 (-3.37, -1.60)* -2.88 (-3.74, -2.01)* -2.66 (-3.56, -1.76)* -2.38 (-3.28, -1.47)*  
APOE ε4 carriers -0.34 (-1.79, 1.11) -1.92 (-3.31, -0.51)* -0.35 (-1.82, 1.11) -0.34 (-1.74, 1.06)  
p for interaction 0.01 0.24 0.008 0.02 0.04
Past smoking §      
APOE ε4 non-carriers -0.21 (-0.89, 0.44) -0.44 (-1.08, 0.20) 0.05 (-0.62, 0.72) -0.39 (-1.06, 0.28)  
APOE ε4 carriers 0.71 (-0.35, 1.78) 0.08 (-0.95, 1.11) 1.35 (0.27, 2.42)* 1.27 (0.25, 2.30)*  
p for interaction 0.11 0.36 0.04 0.006 0.02
Alcohol abstinence #      
APOE ε4 non-carriers -1.24 (-2.18, -0.30)* -3.80 (-4.71, -2.90)* -3.05 (-4.00, -2.10)* -2.57 (-3.52, -1.61)*  
APOE ε4 carriers -2.16 (-3.62, -0.71)* -3.04 (-4.44, -1.63)* -2.88 (-4.34, -1.41)* -3.06 (-4.46, -1.66)*  
p for interaction 0.22 0.43 0.88 0.48 0.37
High alcohol consumption #      
APOE ε4 non-carriers 0.63 (-0.08, 1.34) 1.15 (0.47, 1.84)* 1.13 (0.41, 1.85)* 1.19 (0.47, 1.91)*  
APOE ε4 carriers 1.19 (0.05, 2.32)* 0.90 (-0.19, 1.99) 1.96 (0.82, 3.10)* 0.77 (-0.33, 1.86)  
p for interaction 0.39 0.73 0.23 0.55 0.31
Sedentary habit**      
APOE ε4 non-carriers -0.90 (-1.55, -0.20)* -1.20 (-1.90, -0.50)* -1.50 (-2.23, -0.80)* -1.50 (-2.18, -0.80)*  
APOE ε4 carriers -0.60 (-1.73, 0.53) -1.30 (-2.43, -0.30)* -1.30 (-2.46, -0.20)* -2.00 (-3.12, -1.00)*  
p for interaction 0.92 0.72 0.90 0.25 0.70
Fruit & vegetable consumption less than 2 times/day ††      
APOE ε4 non-carriers -1.50 (-2.15, -0.90)* -3.20 (-3.83, -2.60)* -2.10 (-2.75, -1.50)* -3.10 (-3.73, -2.50)*  
APOE ε4 carriers -1.20 (-2.16, -0.20)* -3.00 (-3.92, -2.00)* -1.30 (-2.29, -0.30)* -2.70 (-3.67, -1.80)*  
p for interaction 0.45 0.59 0.15 0.46 0.69
  1. * p < 0.05.
  2. Mean difference in T-score of cognitive function in models adjusted for age and sex. p from MANCOVA.
  3. §Difference with never smoking. # Difference with moderate alcohol consumption.
  4. ** Difference with non sedentary habit. ††Difference with the group eating fruit & vegetables 2 or more times a day.