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Table 2 Association between health behaviors and cognitive function as a function of APOE ε4 status adjusted for socioeconomic variables.

From: Effect of Apolipoprotein E ε4 on the association between health behaviors and cognitive function in late midlife

 

Memory

Reasoning

Phonemic fluency

Semantic fluency

pfor interaction

Health behaviors

Difference(95% CI)

Difference(95% CI)

Difference(95% CI)

Difference(95% CI)

 

Current smoking §

     

APOE ε4 non-carriers

-2.49 (-3.37, -1.60)*

-2.88 (-3.74, -2.01)*

-2.66 (-3.56, -1.76)*

-2.38 (-3.28, -1.47)*

 

APOE ε4 carriers

-0.34 (-1.79, 1.11)

-1.92 (-3.31, -0.51)*

-0.35 (-1.82, 1.11)

-0.34 (-1.74, 1.06)

 

p for interaction

0.01

0.24

0.008

0.02

0.04

Past smoking §

     

APOE ε4 non-carriers

-0.21 (-0.89, 0.44)

-0.44 (-1.08, 0.20)

0.05 (-0.62, 0.72)

-0.39 (-1.06, 0.28)

 

APOE ε4 carriers

0.71 (-0.35, 1.78)

0.08 (-0.95, 1.11)

1.35 (0.27, 2.42)*

1.27 (0.25, 2.30)*

 

p for interaction

0.11

0.36

0.04

0.006

0.02

Alcohol abstinence #

     

APOE ε4 non-carriers

-1.24 (-2.18, -0.30)*

-3.80 (-4.71, -2.90)*

-3.05 (-4.00, -2.10)*

-2.57 (-3.52, -1.61)*

 

APOE ε4 carriers

-2.16 (-3.62, -0.71)*

-3.04 (-4.44, -1.63)*

-2.88 (-4.34, -1.41)*

-3.06 (-4.46, -1.66)*

 

p for interaction

0.22

0.43

0.88

0.48

0.37

High alcohol consumption #

     

APOE ε4 non-carriers

0.63 (-0.08, 1.34)

1.15 (0.47, 1.84)*

1.13 (0.41, 1.85)*

1.19 (0.47, 1.91)*

 

APOE ε4 carriers

1.19 (0.05, 2.32)*

0.90 (-0.19, 1.99)

1.96 (0.82, 3.10)*

0.77 (-0.33, 1.86)

 

p for interaction

0.39

0.73

0.23

0.55

0.31

Sedentary habit**

     

APOE ε4 non-carriers

-0.90 (-1.55, -0.20)*

-1.20 (-1.90, -0.50)*

-1.50 (-2.23, -0.80)*

-1.50 (-2.18, -0.80)*

 

APOE ε4 carriers

-0.60 (-1.73, 0.53)

-1.30 (-2.43, -0.30)*

-1.30 (-2.46, -0.20)*

-2.00 (-3.12, -1.00)*

 

p for interaction

0.92

0.72

0.90

0.25

0.70

Fruit & vegetable consumption less than 2 times/day ††

     

APOE ε4 non-carriers

-1.50 (-2.15, -0.90)*

-3.20 (-3.83, -2.60)*

-2.10 (-2.75, -1.50)*

-3.10 (-3.73, -2.50)*

 

APOE ε4 carriers

-1.20 (-2.16, -0.20)*

-3.00 (-3.92, -2.00)*

-1.30 (-2.29, -0.30)*

-2.70 (-3.67, -1.80)*

 

p for interaction

0.45

0.59

0.15

0.46

0.69

  1. * p < 0.05.
  2. Mean difference in T-score of cognitive function in models adjusted for age and sex. p from MANCOVA.
  3. §Difference with never smoking. # Difference with moderate alcohol consumption.
  4. ** Difference with non sedentary habit. ††Difference with the group eating fruit & vegetables 2 or more times a day.