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Table 3 Association between health behaviors and cognitive function as a function of APOE ε4 status adjusted for socioeconomic variables.

From: Effect of Apolipoprotein E ε4 on the association between health behaviors and cognitive function in late midlife

 

Memory

Reasoning

Phonemic fluency

Semantic fluency

pfor interaction‡

Health behaviors

Difference†(95% CI)

Difference†(95% CI)

Difference†(95% CI)

Difference†(95% CI)

 

Current smoking §

     

APOE ε4 non-carriers

-1.65 (-2.53, -0.79)*

-1.10 (-1.84, -0.36)*

-1.46 (-2.32 -0.61)*

-0.99 (-1.83, -0.14)*

 

APOE ε4 carriers

0.41 (-1.02, 1.84)

-0.36 (-1.59, 0.86)

0.73 (-0.67, 2.12)

0.88 (-0.42, 2.17)

 

p for interaction

0.01

0.27

0.009

0.02

0.02

Past smoking §

     

APOE ε4 non-carriers

0.17 (-0.47, 0.82)

0.28 (-0.26, 0.83)

0.56 (-0.07, 1.19)

0.19 (-0.42, 0.82)

 

APOE ε4 carriers

0.76 (-0.28, 1.80)

0.15 (-0.75, 1.04)

1.40 (0.38, 2.42)*

1.30 (0.35, 2.25)*

 

p for interaction

0.30

0.68

0.22

0.06

0.17

Alcohol abstinence #

     

APOE ε4 non-carriers

-0.12 (-1.06, 0.81)

-1.07 (-1.86, -0.28)*

-1.21 (-2.13, -0.30)*

-0.51 (-1.40, 0.39)

 

APOE ε4 carriers

-1.56 (-3.00, -0.12)*

-1.65 (-2.88, -0.42)*

-2.00 (-3.40, -0.59)*

-1.97 (-3.28, -0.66)*

 

p for interaction

0.08

0.67

0.58

0.09

0.28

High alcohol consumption #

     

APOE ε4 non-carriers

0.25 (-0.45, 0.94)

0.33 (-0.26, 0.91)

0.55 (-0.13, 1.23)

0.53 (-0.14, 1.20)

 

APOE ε4 carriers

0.91 (-0.20, 2.03)

0.16 (-0.80, 1.11)

1.49 (0.40, 2.58)*

0.15 (-0.86, 1.17)

 

p for interaction

0.37

0.62

0.23

0.48

0.30

Sedentary habit**

     

APOE ε4 non-carriers

-0.37 (-1.05, 0.32)

0.06 (-0.52, 0.64)

-0.66 (-1.33, -0.00)*

-0.52 (-1.18, 0.14)

 

APOE ε4 carriers

-0.03 (-1.15, 1.09)

-0.08 (-1.03, 0.88)

-0.52 (-1.61, 0.57)

-1.14 (-2.15, -0.12)*

 

p for interaction

0.81

0.88

0.64

0.35

0.71

Fruit & vegetable consumption less than 2 times/day ††

     

APOE ε4 non-carriers

-0.60 (-1.22, 0.01)

-1.12 (-1.65, -0.60)*

-0.65 (-1.26, -0.05)*

-1.49 (-2.08, -0.90)*

 

APOE ε4 carriers

-0.49 (-1.47, 0.50)

-1.43 (-2.27, -0.59)*

-0.19 (-1.16, 0.77)

-1.53 (-2.43, -0.64)*

 

p for interaction

0.70

0.74

0.37

0.94

0.82

  1. * p < 0.05.
  2. †Mean difference in T-score of cognitive function in models adjusted for age, sex, employment grade, and education. ‡ p from MANCOVA.
  3. §Difference with never smoking. # Difference with moderate alcohol consumption.
  4. ** Difference with non sedentary habit. ††Difference with the group eating fruit & vegetables 2 or more times a day.
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Molecular Neurodegeneration

ISSN: 1750-1326