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Table 3 Association between health behaviors and cognitive function as a function of APOE ε4 status adjusted for socioeconomic variables.

From: Effect of Apolipoprotein E ε4 on the association between health behaviors and cognitive function in late midlife

  Memory Reasoning Phonemic fluency Semantic fluency pfor interaction
Health behaviors Difference(95% CI) Difference(95% CI) Difference(95% CI) Difference(95% CI)  
Current smoking §      
APOE ε4 non-carriers -1.65 (-2.53, -0.79)* -1.10 (-1.84, -0.36)* -1.46 (-2.32 -0.61)* -0.99 (-1.83, -0.14)*  
APOE ε4 carriers 0.41 (-1.02, 1.84) -0.36 (-1.59, 0.86) 0.73 (-0.67, 2.12) 0.88 (-0.42, 2.17)  
p for interaction 0.01 0.27 0.009 0.02 0.02
Past smoking §      
APOE ε4 non-carriers 0.17 (-0.47, 0.82) 0.28 (-0.26, 0.83) 0.56 (-0.07, 1.19) 0.19 (-0.42, 0.82)  
APOE ε4 carriers 0.76 (-0.28, 1.80) 0.15 (-0.75, 1.04) 1.40 (0.38, 2.42)* 1.30 (0.35, 2.25)*  
p for interaction 0.30 0.68 0.22 0.06 0.17
Alcohol abstinence #      
APOE ε4 non-carriers -0.12 (-1.06, 0.81) -1.07 (-1.86, -0.28)* -1.21 (-2.13, -0.30)* -0.51 (-1.40, 0.39)  
APOE ε4 carriers -1.56 (-3.00, -0.12)* -1.65 (-2.88, -0.42)* -2.00 (-3.40, -0.59)* -1.97 (-3.28, -0.66)*  
p for interaction 0.08 0.67 0.58 0.09 0.28
High alcohol consumption #      
APOE ε4 non-carriers 0.25 (-0.45, 0.94) 0.33 (-0.26, 0.91) 0.55 (-0.13, 1.23) 0.53 (-0.14, 1.20)  
APOE ε4 carriers 0.91 (-0.20, 2.03) 0.16 (-0.80, 1.11) 1.49 (0.40, 2.58)* 0.15 (-0.86, 1.17)  
p for interaction 0.37 0.62 0.23 0.48 0.30
Sedentary habit**      
APOE ε4 non-carriers -0.37 (-1.05, 0.32) 0.06 (-0.52, 0.64) -0.66 (-1.33, -0.00)* -0.52 (-1.18, 0.14)  
APOE ε4 carriers -0.03 (-1.15, 1.09) -0.08 (-1.03, 0.88) -0.52 (-1.61, 0.57) -1.14 (-2.15, -0.12)*  
p for interaction 0.81 0.88 0.64 0.35 0.71
Fruit & vegetable consumption less than 2 times/day ††      
APOE ε4 non-carriers -0.60 (-1.22, 0.01) -1.12 (-1.65, -0.60)* -0.65 (-1.26, -0.05)* -1.49 (-2.08, -0.90)*  
APOE ε4 carriers -0.49 (-1.47, 0.50) -1.43 (-2.27, -0.59)* -0.19 (-1.16, 0.77) -1.53 (-2.43, -0.64)*  
p for interaction 0.70 0.74 0.37 0.94 0.82
  1. * p < 0.05.
  2. Mean difference in T-score of cognitive function in models adjusted for age, sex, employment grade, and education. p from MANCOVA.
  3. §Difference with never smoking. # Difference with moderate alcohol consumption.
  4. ** Difference with non sedentary habit. ††Difference with the group eating fruit & vegetables 2 or more times a day.