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Figure 1 | Molecular Neurodegeneration

Figure 1

From: Heat shock protein 90 in neurodegenerative diseases

Figure 1

Heat shock proteins are induced upon Hsp90 inhibition. (A) Schematic representation of HSF-1 regulation by Hsp90 and its activation by Hsp90 inhibitors. (B) Treatment of cells with heat shock or an Hsp90 inhibitor (Hsp90i) results in HSF-1 trimerization [10]. (C) Systemic administration of the purine-scaffold Hsp90 inhibitor PU-DZ8 to AD transgenic mice results in Hsp70 induction in the brain [29].

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Molecular Neurodegeneration

ISSN: 1750-1326