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Table 1 Identified proteins and related pathways and neurological diseases summary

From: First evidence of overlaps between HIV-Associated Dementia (HAD) and non-viral neurodegenerative diseases: proteomic analysis of the frontal cortex from HIV+ patients with and without dementia

KEGG pathway spot no Ac. No. Name ratio P value Related Neurological disease
Glycolysis/Gluconeogenesis
pathway
387 P09972 Fructose-bisphosphate aldolase C [Homo sapiens] 1.69 0.0009 Schizophrenia, bipolar disorder, and depression [100]
  471 P00338 L-lactate dehydrogenase A chain [Homo sapiens] 1.5 0.039  
  439 P07195 L-lactate dehydrogenase B chain (LDH) [Homo sapiens] 1.43 0.028  
  412 P14550 Alcohol dehydrogenase [NADP+] [Homo sapiens] 1.36 0.028  
  605 P60174 Triosephosphate isomerase [Homo sapiens] -1.32 0.02 Neurodegeneration [101]
  581 Q53G35 Phosphoglycerate mutase 1 (Brain) variant (Fragment) [Homo sapiens] -1.6 0.043 AD [102]
Oxidative phosphorylation pathway 518 B3KP20 cDNA FLJ30970 fis, clone HEART2000444, highly similar to Homo sapiens phospholysine phosphohistidine inorganic pyrophosphate phosphatase (LHPP), mRNA [Homo sapiens] 1.57 0.043 AD [85]
  522 P36543 V-type proton ATPase subunit E 1 [Homo sapiens] 1.55 0.0068  
  658 O75947-2 (ATP5H)Isoform 2 of O75947. [Homo sapiens] 1.48 0.015  
  587 P47985 Cytochrome b-c1 complex subunit Rieske, mitochondrial [Homo sapiens] 1.38 0.013  
  634 O96000 NADH dehydrogenase (ubiquinone) 1 beta subcomplex subunit 10 [Homo sapiens] -1.42 0.0059  
Nitrogen metabolism pathway 363 P15104 Glutamine synthetase [Homo sapiens] 1.85 0.0007 AD [20]
  578 P00918 Carbonic anhydrase 2 [Homo sapiens] -3.11 0.009 Mental retardation,
AD [103, 104]
Arachidonic acid metabolism pathway 494 P16152 Carbonyl r Carbonyl reductase [NADPH] 1 [Homo sapiens] 2 0.014 AD [105]
Purine metabolism pathway 787 P22392 Nucleoside diphosphate kinase B [Homo sapiens] -1.33 0.0061 DS, AD [106]
Arginine and proline metabolism pathway 369 P12532 Creatine kinase, ubiquitous mitochondrial [Homo sapiens] 1.47 0.0006 Alzheimer's and Pick's Disease [17]
Glutathione metabolism pathway 624 P09211 Glutathione S-transferase P [Homo sapiens] -1.64 0.024 Parkinson's disease, AD [107, 108]
MAPK signalling pathway 738 P16949 Stathmin [Homo sapiens] 1.48 0.031 DSand AD [29, 109]
  608 P62993 Growth factor receptor-bound protein 2 [Homo sapiens] 1.29 0.04 AD [110]
Calcium signalling pathway 496 B4DKM5 cDNA FLJ60120, highly similar to Voltage-dependent anion-selective channel protein 2 [Homo sapiens]* 1.57 0.021  
  411 P50148 Guanine nucleotide-binding Protein G(o) subunit alpha [Homo sapiens] 1.36 0.026 Familial Alzheimer's disease [49]
Axon guidance pathway 230 Q16555 Dihydropyrimidinase-related protein 2 [Homo sapiens] 1.57 0.025 AD [14]
Parkinson's disease pathway 384 Q7KYV2 H5 [Homo sapiens]* 1.37 0.035 Autosomal-recessive juvenile parkinsonism [111]
Antigen processing and presentation pathway 189 P11142 Heat shock cognate 71 kDa protein [Homo sapiens] 1.39 0.022 AD [59]
N/A 393 O00154 (ACOT7)Isoform 6 of O00154. [Homo sapiens] 1.64 0.0018  
  394 Q2TU84 Aspartate aminotransferase [Homo sapiens] 1.51 0.0048  
  350 P49411 Elongation factor Tu, mitochondrial [Homo sapiens] 1.35 0.008 Infantile Encephalopathy [24]
  723 P61601 Neurocalcin-delta [Homo sapiens]* 1.57 0.043 AD [53]
  475 B4DGP9 cDNA FLJ54102, highly similar to Beta-soluble NSF attachment protein [Homo sapiens] 1.53 0.033  
  458 P62879 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 [Homo sapiens] 1.73 0.0089 AD [46]
  784 A8MVL5 Putative uncharacterized protein PRDX5 [Homo sapiens] -1.88 0.032 AD and parkinson [112, 113]
  1. Note: Most proteins in this table are involved in gene-ontology metabolic process except those proteins marked by *.