Skip to main content
Figure 3 | Molecular Neurodegeneration

Figure 3

From: No dramatic age-related loss of hair cells and spiral ganglion neurons in Bcl-2 over-expression mice or Bax null mice

Figure 3

Comparison of age-related loss of hair cells between wild-type and bcl-2 transgenic mice. Mean (+SD) inner and outer hair cell density at four basal-apical locations versus age (18 and 24 months) and BCL-2 genotype. Averaged data for 2 month-old control female mice (n = 5), pooled by genotype, provided normal comparison numbers. Both wild type (n = 4) and transgenic mice (n = 4) showed progressive loss of inner (IHCs) and outer hair cells (OHCs), beginning in the base. There was no significant tendency for BCL-2 transgenic to retain hair cells.

Back to article page

Molecular Neurodegeneration

ISSN: 1750-1326