Figure 3

Aβ oligomers decrease mainly the NMDA current. (A) Average (20 sweeps) EPSCs in control (left), after treatment with CNQX (gray trace) or CNQX plus Aβ oligomers (black trace) (right) at -80 and +40 mV of holding potential obtained from a same neuron. B) Average (20 sweeps) EPSCs in control (left), after treatment with APV (gray trace) or APV plus Aβ oligomers (black trace) (right) at -80 and +40 mV of holding potential. C) Summary data of normalized amplitude (to control) of evoked EPSCs obtained from experiments on A (n = 6) and B (n = 5). Bar represents the mean ± SEM (*p < 0.05 Student's t test).