Figure 4

Wnt-5a occludes the synaptic transmission depression induce by Aβ oligomers. (A), Time course of the treatment with Aβ plus Wnt-5a (first arrow) and to extra treatment with Aβ oligomers (second arrow). (B), Average (20 sweeps) EPSCs in control (light gray), after 40 min of treatment with Aβ plus Wnt-5a treatment (black) and after to extra treatment with Aβ oligomers (dark gray), recorded at -80 mV holding potential. Mean of normalized amplitude of evoked EPSCs in control, Aβ and Aβ plus Wnt-5a treated slices (right) (n = 6). (C), Superimposed, average EPSCs evoked by paired pulse test at +40 and -80 mV of holding potential (left). Mean of facilitation index measured before (control) and after Wnt-5a plus Aβ or Aβ alone treatment application (right). Bar represents the mean ± SEM (*p < 0.05 Student's t test).