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Table 1 Wnt-5a ligand induces the clustering of PSD-95, effect of Aβ oligomers: Immunofluoresce in mature hippocampal neurons of 21DIV, every treatment were by 1 h.

From: Wnt-5aoccludes Aβ oligomer-induced depression of glutamatergic transmission in hippocampal neurons

Treatments

PSD-95 (Number of clusters in 100 μM of neurite)

Control

24 ± 3

Wnt-5a

46 ± 8*

Wnt-5a/sFRP

25 ± 4

Aβ

9 ± 3*

Aβ/Wnt-5a

23 ± 2

Aβ/Wnt-5a/sFRP

11 ± 2*

  1. Aβ 1 μM, (n = 3). *P < 0.01 respect to the control
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Molecular Neurodegeneration

ISSN: 1750-1326