Figure 2

BACE1^-/- mice have increased sensitivity to KA-induced seizures compared to wild-type littermates. BACE1^-/- mice and wild-type littermate controls were injected with 15 mg/kg of KA and observed for 120 minutes. Seizures were rated (0-6) on a modified Racine scale at each 5-minute interval. A. Average seizure stage for each group over time. B. Sum of all seizure scores over 120 minutes. Error bars indicate SEM, * p < 0.05, **p < 0.01; n = 10, 11 for BACE1^+/+ and BACE1^-/- groups, respectively. C. Histogram of highest seizure stage reached overall by each mouse.