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Figure 3 | Molecular Neurodegeneration

Figure 3

From: BACE1-/- mice exhibit seizure activity that does not correlate with sodium channel level or axonal localization

Figure 3

KA-induced cell death in BACE1-/- mice. Mice were injected with 20 mg/kg of KA and recovered for 7 days before brains were harvested and sectioned. A. Cresyl violet staining reveals extensive degeneration in the CA1/2 region of the hippocampus in some BACE1-/- mice (right) but no BACE1+/+ littermates (left). 3 of 10 BACE1-/- mice had cell loss as demonstrated. 0 of 7 wild-type mice had cell loss. Lower panels are higher magnification images of region indicated by box in upper panels. B. TUNEL staining performed on adjacent sections indicates DNA fragmentation in many cells of the CA1/2 region in 3 of 10 BACE1-/- mice (right). No TUNEL-positive cells were seen in any of 7 KA-treated wild-type littermates (left) nor in BACE1-/- mice that lacked cell loss.

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