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Figure 1 | Molecular Neurodegeneration

Figure 1

From: Increased expression of RXRα in dementia: an early harbinger for the cholesterol dyshomeostasis?

Figure 1

Schematic diagram of LXR/RXR activation mechanism (adapted from the references cited above). In the absence of a ligand, LXR/RXR heterodimers are bound to the LXREs in the promoter region of target genes and in complex with corepressors (SMRT or NCoR). Ligand binding (e.g., oxysterols) induces a dissociation of corepressors and recruitment of coactivators and the target gene expression is induced.

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