Table 2 BACE1 activity and biochemical markers in CSF and BACE1 genotypes in AD patients
BACE1genetic variants | ||||
|---|---|---|---|---|
CSF protein | CC | CG | GG | p-value |
Total-tau (pg/ml) | 628.8 ± 38.7 | 612.7 ± 29.3 | 610.0 ± 33.4 | 0.699 |
Phospho-tau181 (pg/ml) | 79.7 ± 3.9 | 73.8 ± 2.8 | 77.7 ± 3.4 | 0.506 |
Aβ42 (pg/ml) | 408.7 ± 11.8 | 419.4 ± 9.2 | 408.3 ± 9.9 | 0.575 |
Aβ40 (pg/ml) | 4869.9 ± 196.4 | 4894.8 ± 238.6 | 5030.7 ± 219.6 | 0.854 |
BACE1 (pM) | 29.2 ± 2.5 | 31.8 ± 2.0 | 33.6 ± 3.3 | 0.765 |
α-sAPP (ng/ml) | 645.8 ± 77.0 | 660.5 ± 40.6 | 620.5 ± 41.8 | 0.962 |
β-sAPP (ng/ml) | 393.3 ± 37.8 | 408.0 ± 24.9 | 399.6 ± 22.6 | 0.965 |