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Figure 15 | Molecular Neurodegeneration

Figure 15

From: Presenilin-1 regulates induction of hypoxia inducible factor-1α: altered activation by a mutation associated with familial Alzheimer's disease

Figure 15

Activation of HIF-1α downstream target genes in Psen1-/- neurons treated with cobalt chloride or insulin. Levels of Vegf RNA were determined by qPCR following three hours of treatment of wild type or Psen1-/- primary neuronal cultures with cobalt chloride (A, n = 3 cultures per group) or seven hours with insulin (B, n = 2 cultures per group). Samples were run in triplicate and normalized to Ppia. Asterisks indicate p < 0.01 vs. untreated control (unpaired t-tests).

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Molecular Neurodegeneration

ISSN: 1750-1326