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Figure 7 | Molecular Neurodegeneration

Figure 7

From: Presenilin-1 regulates induction of hypoxia inducible factor-1α: altered activation by a mutation associated with familial Alzheimer's disease

Figure 7

Basal levels of HIF-1α are decreased in Psen1-/- fibroblasts. Shown are prolonged exposures of Western blots from non-stimulated Psen1+/+ and Psen1-/- fibroblasts. A representative experiment that was performed multiple times is shown in panel A. In panel B, the experiment in (A) is quantified (asterisk indicates p = 0.0005, unpaired t-test). In panel C, levels of HIF-1α RNA were determined in Psen1 +/+ and Psen1-/- fibroblasts by qPCR (n = 3 cultures per group). Samples were run in triplicate and normalized to the geometric mean of Ppia and Gusb. Asterisk (*) indicates p = 0.0008.

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Molecular Neurodegeneration

ISSN: 1750-1326