The biochemical aftermath of anti-amyloid immunotherapy

Table 3 Summary of Clinico-Neuropathology Analysis in UCSD AN-1792-Immunized Cases

Case ID	Blessed [63]	MMSE	Total plaque	Neuritic plaques	CAA	Neuropathology diagnosis
19	26	8	23	7	3	Lewy body Variant of AD
20	17	18	50	0	2	AD
22	28	10	4	3	0	HS, severe frontal lobe atrophy

MMSE, mini-mental state examination; CAA, cerebral amyloid angiopathy; AD, Alzheimer's diease; HS, hippocampal sclerosis. The counts are representative from the frontal cortex. For each case, 3 sections were analyzed. Total plaques include diffuse and mature with a maximum score of 50 (100 × magnification). Neuritic plaques are defined as those containing a corona of dystrophic neurites with a maximum score of 50 (100 × magnification). Tangles were assessed at 400 × magnification with a maximum score of 50. CAA was assessed as 0, none; 1, mild; 2, moderate; 3, severe using thioflavine-S staining.

ISSN: 1750-1326