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Table 1 Co-localization of the Wt APP-GFP protein with the endocytic markers Transferrin, Rab 5, and Rab 7.

From: Retrieval of the Alzheimer's amyloid precursor protein from the endosome to the TGN is S655 phosphorylation state-dependent and retromer-mediated

 

Wt APP-GFP co-localization coefficients (%)

 

In cytoplasmic vesicles

In cell (cytoplasmic vesicles and Golgi)

Transferrin

18.8 ± 0.3

34.5 ± 2.4

Rab 5

19.5 ± 0.7

30.3 ± 2.4

Rab 7

15.2 ± 1.2

36.6 ± 2.0

  1. The co-localization coefficients presented reflect the percentage of APP-GFP pixels co-localizing with Transferrin, Rab 5 or Rab 7 pixels, respectively, in cytoplasmic vesicles only or in total cell. Total number of pixels in the APP-GFP channel is taken as 100%. Values are mean ± SEM (n=10).