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Figure 1 | Molecular Neurodegeneration

Figure 1

From: Progranulin modulates zebrafish motoneuron development in vivoand rescues truncation defects associated with knockdown of Survival motor neuron 1

Figure 1

Zebrafish PGRN-A in situ expression in the Spinal cord and MNs. Lateral view of 24-27 hpf embryos revealed zfPGRN-A expression within the Peripheral and Central Nervous systems. In the head region, zfPGRN-A is expressed at 24 hpf in the head and brain particularly in the tectum, midbrain-hindbrain boundary and eye (Panel A). The sense control displayed minimal signal (Panel B). In addition zfPGRN-A is also expressed at 27 hpf in the somite boundaries (Panel C). At greater magnification of the boxed area in Panel C, zfPGRN-A expression in the somite boundaries is more apparent together with expression in the motoneurons (Panel D). Abbreviations: T: Tectum; E:Eye, MHB:Mid-Brain, Hind-brain Boundary; SB:Somite Boundary, MN:Motoneurons; ICM: Intermediate cell mass. Images were captured at 6X magnification and the hatched box was further subject to 2-3X Zoom

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Molecular Neurodegeneration

ISSN: 1750-1326