Skip to main content
Figure 7 | Molecular Neurodegeneration

Figure 7

From: Progranulin modulates zebrafish motoneuron development in vivoand rescues truncation defects associated with knockdown of Survival motor neuron 1

Figure 7

Progranulin protects CaP MNs in a model of Spinal Muscular Atrophy SMA): zfPGRN-A mRNA co-injection partially rescues SMN-MO induced CaP MN defects. (A, B) Lateral views of embryos injected with 9 ng SMN-MO and (C) embryos co-injected with 9 ng SMN-MO + 100 pg zfPGRN-A mRNA. Symbols as in Figure 1. Truncated (A) and branched (B) neurons were observed upon injection of SMN MO while co-injection with zfPGRN-A rescued truncation (white arrow) and increased axon branching (C). Abbreviations: T-truncation; B-Branching. Scale Bar = 50 μm.

Back to article page

Molecular Neurodegeneration

ISSN: 1750-1326