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Figure 3 | Molecular Neurodegeneration

Figure 3

From: Fcγ receptors are required for NF-κB signaling, microglial activation and dopaminergic neurodegeneration in an AAV-synuclein mouse model of Parkinson's disease

Figure 3

Effect of α-SYN over-expression on the transcription of NF-κB components and the pro-inflammatory mediator in wild-type and FcγR-/- mice at two weeks. There was significant increase in the mRNA level of A) NF-κB p65, B) NF-κB p50, C) intercellular adhesion molecule 1(ICAM-1) in the WT SYN group compared to the WT GFP group. **p < 0.01, *p < 0.05 WT GFP vs WT SYN; and the mRNA level of NFκB p65 was decreased in FcγR-/- SYN mice compared with FcγR-/- GFP mice. **p < 0.01 FcγR-/- SYN vs FcγR-/- GFP. One-way ANOVA with Fisher PLSD post hoc test, GAPDH, glyceraldehyde-3-phosphate dehydrogenase.

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Molecular Neurodegeneration

ISSN: 1750-1326