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Figure 6 | Molecular Neurodegeneration

Figure 6

From: Fcγ receptors are required for NF-κB signaling, microglial activation and dopaminergic neurodegeneration in an AAV-synuclein mouse model of Parkinson's disease

Figure 6

α-SYN induced neuroinflammation model. Over-abundance of α-SYN leads to the expression of a specific antigen, which induces IgG generation. The binding of IgG and FcγR on the surface of microglia results in the downstream signaling pathways, in which NF-κB is the key transcription factor, and causes microglial activation. Microglial activation results in a flooding of surrounding tissue with a variety of neurotoxic substances such as cytokines that ultimately injure neurons in the SN.

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Molecular Neurodegeneration

ISSN: 1750-1326