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Figure 1 | Molecular Neurodegeneration

Figure 1

From: Expression of human A53T alpha-synuclein in the rat substantia nigra using a novel AAV1/2 vector produces a rapidly evolving pathology with protein aggregation, dystrophic neurite architecture and nigrostriatal degeneration with potential to model the pathology of Parkinson's disease

Figure 1

Colocalization of tyrosine hydroxylase and alpha-synuclein or GFP in the substantia nigra. Immunofluorescent staining of tyrosine hydroxylase (A, E), GFP (B), and human alpha-synuclein (F) 3 weeks following AAV1/2 injections. Panels C and G represent merged images of A + B and E + F, respectively. Panels D and H represent high power confocal images revealing aggregates of human alpha-synuclein and GFP within a TH neuron of the substantia nigra and confirmed by the orthogonal view of each panel. Scale bar is 500 μm.

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Molecular Neurodegeneration

ISSN: 1750-1326