MB treatment reduces tau levels, but does not affect pathology in mice with pre-existing tangle formation and neurodegeneration. (A) Western blot analysis of tau protein levels from hippocampal lysates. (B) Quantitation of the optical density as a percentage of saline treated rTg4510 mice shows a significant difference in pS202/T205 and total tau levels, *p < 0.05. (C) Representative images of the gallyas silver stain. Scale bar, 200 μm. (D) High magnification images of the gallyas silver stain. Scale bar, 20 μm. (E) Percentage of area of silver positive staining shows no statistical difference between the means (n = 2 per group). (F) Representative images of the staining of neuronal nissl substance in the ipsilateral side of drug infusion (right hippocampus). Scale bar, 200 μm. (G) Quantitation of the percent area positive for nissl staining of ipsilateral versus the contralateral brain side of each group of mice shows that there is no detectable neuron loss due to pump implantation.