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Figure 1 | Molecular Neurodegeneration

Figure 1

From: Insulin deficiency exacerbates cerebral amyloidosis and behavioral deficits in an Alzheimer transgenic mouse model

Figure 1

The body weight, blood glucose and serum insulin levels in APP/PS1 mice. APP/PS1 mice were injected intraperitoneally with STZ (90 mg/kg) for 2 consecutive days, while age-matched control APP/PS1 mice received citrate buffer only. (A) The changes in body weight in vehicle controls and STZ-induced diabetic APP/PS1 mice. From week 12 to 20 after STZ treatment, the body weights of STZ-treated mice were lower than those of the vehicle controls. (B) The levels of blood glucose in controls and STZ-treated APP/PS1 mice. From week 1 to 20, STZ treatment significantly increased the levels of blood glucose, compared with controls. (C) At the 20th week after STZ treatment, the serum insulin level was measured. A significant reduction in serum insulin levels could be detected in STZ-induced diabetic APP/PS1 mice, compared with vehicle control mice. *p < 0.05; **p < 0.01 (n = 7).

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Molecular Neurodegeneration

ISSN: 1750-1326