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Figure 2 | Molecular Neurodegeneration

Figure 2

From: Insulin deficiency exacerbates cerebral amyloidosis and behavioral deficits in an Alzheimer transgenic mouse model

Figure 2

Administration of STZ downregulates the phosphorylation levels of IR. (A) Western blots showing the expression levels of phosphorylated insulin receptor (p-IR) and total IR proteins in APP/PS1 transgenic mouse brain 20 weeks after STZ administration. β-actin was used as a loading control. (B) There were no significant differences in total IR levels between vehicle controls and STZ-treated mice. (C) Insulin deficiency induced by STZ administration led to a marked reduction in the p-IR level in the transgenic mouse brain. (D) The ratio of p-IR/IR was significantly reduced in STZ-treated mouse brain, compared with the vehicle control. **p < 0.01 (n = 7).

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Molecular Neurodegeneration

ISSN: 1750-1326