Figure 6

STZ treatment exacerbates spatial learning impairment in APP/PS1 mice. Morris water maze tests consisted of 2 days of visible platform training, 5 days of hidden platform testing, and a probe trial 24 h after the last hidden platform test. (A, B) The visible platform tests showed that no significant differences in escape latency and swimming distances were detected between vehicle and STZ-treated transgenic mice. (C, D) The hidden platform tests showed that STZ treatment significantly increased both the escape latency and swimming length from the 2nd to 5th day. (E) The probe trial test showed that administration of STZ significantly reduced the time that mice traveled into the center of the quadrant, where the hidden platform was previously located. *p < 0.05, **p < 0.01 (n = 7).