Aminopeptidases do not directly degrade tau protein

Table 1 Identification of Tau degradation products by mass spectral peptide fingerprinting.

Protein Band	Calc'd (M+H⁺)	Expt'l (M+H⁺)	Peptides identified
N1	2069.89	2069.67	⁶QEFEVMEDHAGTYGLGDR
	2181.90	2181.74	²⁵DQGGYTMHQDQEGDTDAGLK
	2424.13	2424.89	⁴⁵AEEAGIGDTPSLEDEAAGHVTQAR
	1393.63	1393.50	¹³⁷SGYSSPGSPGTPGSR
	842.55	842.43	²¹⁷VQIINKK
	1980.09	1979.87	²⁴¹HVPGGGSVQIVYKPVDLSK
N3	2069.89	2069.81	⁶QEFEVMEDHAGTYGLGDR
	2424.13	2424.05	⁴⁵AEEAGIGDTPSLEDEAAGHVTQAR
	1393.63	1393.61	¹³⁷SGYSSPGSPGTPGSR
	1066.59	1066.55	¹⁵⁴TPSLPTPPTR
	842.55	842.50	²¹⁷VQIINKK
C1	1420.78	1420.64	¹⁵⁴TPSLPTPPTREPK
	842.55	842.48	²¹⁷VQIINKK
	1974.00	1973.90	²⁶⁴CGSLGNIHHKPGGGQVEVK
	1578.82	1578.76	²⁹⁶IGSLDNITHVPGGGNK
	978.54	978.51	³¹⁸LTFRENAK
	1101.55	1101.52	³³⁸SPVVSGDTSPR
	1381.66	1381.61	³⁸¹QGLLEHHHHHH
C3	842.55	842.44	²¹⁷VQIINKK
	1578.82	1578.67	²⁹⁶IGSLDNITHVPGGGNK
	978.54	978.46	³¹⁸LTFRENAK
	1101.55	1101.45	³³⁸SPVVSGDTSPR
	1381.66	1381.54	³⁸¹QGLLEHHHHHH

ISSN: 1750-1326