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Table 2 Inhibition of PSAsf Tau cleaving activity by protease inhibitors

From: Aminopeptidases do not directly degrade tau protein

Substrate

% Activity Remaining

 

Bestatin

Puromycin

o-phenanthroline

PMSF

 

(2 mM)

(2 mM)

(2 mM)

(2 mM)

Alanine 4MNA

0

0

0

79

Dynorphin A

0

0

0

79

  1. PSAsf was preincubated with protease inhibitors at 2 mM on ice for 15 min. PSA activity was then assayed with alanine 4MNA, Dynorphin A. PSAsf incubated with buffer was taken as 100% to determine the remaining PSA activity of each treatment.