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Figure 2 | Molecular Neurodegeneration

Figure 2

From: Age-dependent changes in TDP-43 levels in a mouse model of Alzheimer disease are linked to Aβ oligomers accumulation

Figure 2

Age-dependent changes in TDP-43 and TDP-35 levels. (A) Representative Western blots of proteins from the low salt fraction extracted from 2-, 6- and 12-month-old NonTg mice and probed with a polyclonal antibody raised against TDP-43 antibody. A longer exposure time was necessary to see the less abundant low molecular weight fragments. (B) Quantitative analysis of the blots shows that the levels of TDP-43 and TDP-35 were similar across the three different ages analyzed (n = 6/time-point). (C) Representative Western blots of proteins from the low salt fraction extracted from 2-, 6- and 12-month-old 3×Tg-AD mice and probed with a polyclonal antibody raised against TDP-43 antibody. (B) Quantitative analysis of the blots shows that the levels of TDP-43 and TDP-35 were significantly higher at 6 months of age (n = 6/time-point). Abbreviation: exp = exposure. Data are presented as ± SEM and analyzed by one way ANOVA.

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Molecular Neurodegeneration

ISSN: 1750-1326