Figure 1
From: A hereditary spastic paraplegia mutation in kinesin-1A/KIF5A disrupts neurofilament transport
Sequence comparison of mouse and human kinesin-1A. Sequence alignment of kinesin-1A in mice (Genbank Accession number NP_001034089) and humans (Genbank Accession number NP_004975). The motor domain spans residues 1 through 336 and is identical except for conserved substitutions at residues 41 and 218. The N256S mutation occurs at an invariant asparagine residue (highlighted in inverted contrast) located in the switch II loop/helix motif of the microtubule binding site.