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Figure 5 | Molecular Neurodegeneration

Figure 5

From: ADAR2-dependent RNA editing of GluR2 is involved in thiamine deficiency-induced alteration of calcium dynamics

Figure 5

Effects of TD on ADAR2 self-editing activity in cultured cortical neurons. A: Cortical neurons were treated with amprolium (Amp, 0 or 1 mmol/L) for 1 or 4 days (TD1 or TD4). The expression of ADAR2 mRNA was analyzed by RT-PCR as described under the Materials and Methods. The products of alternative splicing of ADAR2 mRNA (+ 47 nt) were examined. B: The self-editing efficiency of ADAR2 mRNA was quantified by calculating the percentage of alternative splicing products (+47 nt). The results were expressed as the mean ± SEM. *p < 0.05. The experiments were replicated three times.

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Molecular Neurodegeneration

ISSN: 1750-1326