Figure 6
From: α-synuclein induced synapse damage is enhanced by amyloid-β1-42
αSN enhanced the Aβ 1-42 -induced loss of synaptophysin. (A) The synaptophysin content of cortical neurons incubated for 24 hours with Aβ1-42 (●) Aβ1-42 premixed with αSN (1:2) (■) or Aβ1-42 premixed with βSN (1:2) (□). Values shown are the mean amount of synaptophysin (units) ± SD, n = 15. (*) = amount of synaptophysin significantly lower than in neurons incubated with the same concentration of Aβ1-42 alone (P < 0.01). (B) The synaptophysin content of cortical neurons incubated for 24 hours with PrP82-146 (●) or PrP82-146 that had been premixed with αSN (1:5) (○). Values shown are the mean amount of synaptophysin (units) ± SD, n = 15.