Figure 7
From: α-synuclein induced synapse damage is enhanced by amyloid-β1-42
αSN did not affect the accumulation of Aβ 1-42 in synapses. (A) The amount of biotinylated-Aβ1-42 found in synaptosomes derived from cortical neurons incubated for 1 hour with 100 nM Aβ1-42 (□) or 100 nM Aβ1-42 that had been pre-mixed with 500 nM αSN (■). Values shown are the mean amount of Aβ1-42 expressed as a % of the amount added ± SD, n = 12. (B) Immunoblot showing the amount of αSN in synaptosomes collected from cortical neurons incubated with 200 nM αSN alone or with 200 nM αSN pre-mixed with Aβ1-42 (50:1).